This study shows the proof of principle that such manipulation is possible. They used iron oxide nanoparticles that can be heated by radio waves and coated them with an antibody against a temperature sensitive calcium channel. They injected the nanoparticles into tumors grown under the skin of mice. Nanoparticles attached to the calcium channels and in response to radio waves they heated the channel molecules to their activation temperature of 42 C. The channels opened and subsequent influx of calcium activated engineered calcium sensitive insulin gene within the cells. Insulin was produced and secreted from the cells and a drop in glucose levels in mice was observed.