Friday, July 29, 2011

Remove AVG Safe Search from Chrome

After installing AVG, search in Google Chrome (via address bar) is changed to AVG Safe search.

To revert to the defaults:

Options/Basics
Under Search change to Google

This will revert search to Google but with an AVG Site Reports check for every site.

To remove AVG Site Reports check:

Type about:plugins
Disable AVG Internet Security

Sunday, July 10, 2011

How to convert a brain cell into a heart cell


This paper demonstrates how a cell type can be reprogrammed / converted into a distinct cell type without intermediates. This idea should have come before, I wonder why no one tried this. 

Transfecting whole mRNA extracts from heart cells into brain cells that will produce heart specific proteins/transcription factors that will subsequently take control of the cells transcription program and turn them into heart cells.

Previously cells were reprogrammed by integrating 4 genes (initially Oct4, Sox2, Klf4, c-Myc) into the genome using retroviruses. This will turn the cells into a pluripotent state (iPS cells) and subsequently they could be differentiated into any cell type (e.g a heart cell). This new method might overcome the risks of using retroviruses and also potential tumor formation from the pluripotent intermediates.

Link to the original article at PNAS:
http://www.pnas.org/content/early/2011/06/29/1101223108.full.pdf+html?with-ds=yes