Thursday, March 3, 2011

Reprogrammed stem cells and mutations

The use of iPS cells in therapy may have it's advantages as the absence of immune response of a recipient, which makes them a good alternative to the embryonic stem cell therapy, they may be more error prone and contain more single nucleotide mutations then embryonic stem cells. Whether this is the artifact of a culturing of cells where mutations of key regulator genes may be favorable and thus kept in a cell population or it is the effect of transfection procedure remains still unknown.

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