Thursday, March 3, 2011

Reprogrammed stem cells and mutations

The use of iPS cells in therapy may have it's advantages as the absence of immune response of a recipient, which makes them a good alternative to the embryonic stem cell therapy, they may be more error prone and contain more single nucleotide mutations then embryonic stem cells. Whether this is the artifact of a culturing of cells where mutations of key regulator genes may be favorable and thus kept in a cell population or it is the effect of transfection procedure remains still unknown.

Tuesday, March 1, 2011

The Mere Existence of Whales

Given their enormous size and thus the number of cells and cell divisions, whales should have much greater incidence of cancer and thus will not be able to survive not even close to the life span of humans. Yet they live up to 100 and more year. What are whales cancer fighting strategies and mechanisms and why should we focus on larger organisms in the ongoing cancer research.